Tianeptine Sodium CAS: 30123-17-2 5-dioxide Stablon S-Dioxide Sodium Munyu

SHANDISA

Tianeptine sodium munyu inonzi tricyclic antidepressant, uye maitiro ayo ekudzivirira kuora mwoyo akasiyana nemaitiro echinyakare tricyclic antidepressants.Inogona kuwedzera reuptake ye5-HT munzvimbo ye synaptic, uye inogona kuva nemigumisiro yekuvandudza kufambisa kwe5-HT neurons.Hapana hukama hwecholine kana adrenaline receptors.Antidepressant efficacy yakafanana ne tricyclic, asi kushivirira kuri nani pane tricyclic.Mukuedza kwemhuka, inogona kuwedzera basa rinongoitika remaseru epiramidhi muhippocampus uye nekumhanyisa kupora kwavo mushure mekuvhara basa.Chemicalbook yakawedzera kudzoreredzwa kweserotonin nemaneuroni mucerebral cortex uye hippocampus.Kutorwa kwe tineptine sodium mudumbu rekudya kunokurumidza uye kwakakwana.Kukurumidza kugovera, PPB kusvika ku94%.Yakanga yakagadziriswa zvachose muchiropa ne β-oxidation uye N-demethylation, uye kubviswa kwekupedzisira T1 / 2 kwaiva pfupi pa 2.5h.Mushonga ushoma kwazvo (8%) wakaburitswa kubva muitsvo, kunyanya metabolites kubva muweti.Varwere vane renal insufficiency vakabvisa T1/2 kwenguva yakareba 1h.