Hygromycin A CAS:6379-56-2 Homomycin
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Chemical Properties:
Upfu chena.Weakly acidic.Kunyungudika zvakasununguka mumvura nedoro.Yakagadzirwa neStreptomyces hygroscopicus.
Zvishandiso:
Hygromycin A, mushonga unorwisa mabhakitiriya unoregeredzwa, unosarudza kuuraya utachiona hunokonzera chirwere cheLyme.Yakakwanisa kurapa chirwere cheLyme mumakonzo pasina kukanganisa microbiome.
Mushonga (broad-spectrum antibiotic).
Tsanangudzo ChEBI: Chigadzirwa chechisikigo chinowanikwa muStreptomyces marudzi.
SR 9009 is a synthetic REV-ERB agonist inodzora hunhu hwecircadian uye metabolism;ine mukana wekushandisa mukurapa kwekusagadzikana kwekurara uye metabolic zvirwere.Mushonga unotungamira wekirasi nyowani yemishonga yegomarara ine chekuita nemuviri wecircadian wachi.
SR9009, inozivikanwawo seStenabolic, mushonga wekutsvagisa seagonist weREV-ERB.
REV-ERB-α uye REV-ERB-β, manuclear receptors maviri, ane basa rakakosha mukugadzirisa mataurirwo emapuroteni ewachi anotyaira rhythms mukuita uye metabolism.
In vitro: Zvese zviri zviviri SR9009 neanalogi yayo SR9011 inogona kuwedzera dhigirii-inoenderana neREV-ERB-inotsamira kudzvanyirira chiitiko chakaongororwa muHEK293 maseru anoratidza chimaeric Gal4 DNA inosunga domain: REV-ERB ligand binding domain α kana β uye Gal4-inopindura luciferase reporter. .Pamusoro pezvo, SR9009 yakawanikwa ichikwanisa kudzvanya BMAL1 messenger RNA kutaura muHepG2 masero mune REV-ERB-α/β-inotsamira.
In vivo: Mice dzakabatwa nedoro rimwe chete re SR9009, SR9011 kana motokari panguva yecircadian 6 (CT6 (6h mushure memwenje) mushure memazuva 12 muD / D mamiriro anoratidza kutaura kwepamusoro kweRev-erb-α. jekiseni harina kukonzeresa kukanganisa mukuita kwe circadian locomotor.Mukupesana, kutonga kwedosi rimwechete re SR9009 kana SR9011 kwakatungamira mukurasikirwa kwekuita kwelocomotor panguva yerima yenyaya. nekubvumidzwa kwemishonga mukati measingasviki 24h.
