HU-210 CAS NO: 112830-95-2

HU-210 ndiyo (--) enantiomer ye11-OH-D 8-THC-DMH, ine zvinenge zvese zviitiko zve cannabinoids, nepo (+) enantiomer, inonzi HU-211, haishande se cannabinoid, asi. inoshanda pachinzvimbo se cannabinoid seanopikisa NMDA ane neuroprotective mhedzisiro.

HU-210 inogona kukurudzira kuwanda, asi kwete kusiyanisa, kweembryonic hippocampal neural stem masero uye masero ekutanga kuburikidza nekuita CB 1 receptor, G i / o protein, uye ERK inoratidzira sequentially.Uku kukura kwetsinga kunoratidzawo kudiwa kwe-anti-anxiety uye anti-depressive effects.

Pamwe pamwe nemamwe maitiro ekugadzira cannabinoids, akadai seWIN 55,212-2 uye JWH-133, HU-210 inodzivirira kurwisana nekuputika kunokonzerwa neAlzheimer's disease-yakabatana beta amyloid, kunze kwekudzivirira kukanganisa kwekuziva uye kurasikirwa kwe neuronal markers.Ichi chinopesana nekuputika chinokonzerwa nekushandiswa kwe cannabinoid receptors, iyo inodzivirira kushandiswa kwehutachiona hwehutachiona hwe microglia.Mukuwedzera, cannabinoids yakabvisa zvachose neurotoxicity yakabatana ne microglial cell activation mumakonzo mhando.

HU-210 ine simba painkiller ine zvakawanda zvakafanana mhedzisiro seyakasikwa THC.

Iyo yemuromo LD50 yeHU-210 ndeye 5,000mg/kg mumakonzo uye 14,200mg/kg mutsuro.Iyo LDLO (yakaderera inouraya dose) yeHU-210 muvanhu i143mg/kg.Iyo LD50 ye caffeine inofungidzirwa kuva 150-200 mg / kg.Delta-8-THC LD50 haisati yasimbiswa.Muchidzidzo che1973, tsoko nembwa dzakapihwa 9,000 mg/kg yeDelta-8-THC dzakanga dzisingaurayi.