China Hot Sale CAS 7361-61-7 Xylazine cannabinoids chena poda

Tsanangudzo

Xylazine inonzi agonist ye α2-adrenergic receptors (Ki = 194 nM).Ndiyo analog ye clonidine, α2-adrenergic receptor agonist inoshandiswa kuderedza ropa.Xylazine inoshandiswa sedation, anesthesia, uye analgesia mumhuka dzisiri dzevanhu.Ichi chigadzirwa chinowanikwawo seanalytical reference standard.
Muvambi Xylazine,Bayer

Uses

Antinociceptive; Alpha-2 adrenergic agonist
Uses

Xylazine iri α2 kirasi yeadrenergic receptor agonist.Xylazine inonzi clonidine analoque inoshanda pane presynaptic uye postsynaptic receptors se 2-adrenergic agonist.
Manufacturing Process

2,6-Dimethylphenyl isothiocyanate, 31.0 g (0.2 mole), yakagadzirwa kubva ku2,6- dimethylaniline ine thiophosgene, yakawedzerwa kudonha panguva ye15 min kusvika pakusimwa kwakanyatsogadzirwa kwe15.0 g (0.2 mole) ye3-aminopropanol-1 mu. 100 ml ether.Ether yakatanga kufashaira.Kukurudzira pasi reflux kwakaenderera mberi kwemaminetsi makumi matatu, uye ether yakabva yabviswa.Iyo yakasara yakabatwa ne 100 ml ye concentrated hydrochloric acid uye yakabikwa pasi pe reflux ye 30 min.Mushure mekutonhodzwa, yakanyungudutswa nemvura, yakasefa isina tsvina, uye hwaro hwacho hwakanatswa nekuwedzerwa kweconcentrated sodium hydroxide solution.Kana yadzokororwa kubva kubenzene-ligroin, musanganiswa unobva 2-(2,6- dimethyl-phenylamino)-4H-5,6-dihydro-1,3-thiazine, inonyunguduka 140-142°C (inoburitsa 90% yedzidziso. )
Therapeutic Basa

Analgesic, Anesthetic

General Description

Xylazine inosungunuka mu methanol (50 mg / ml), ichipa mhinduro yakajeka, isina ruvara.Iyo zvakare inonyungudika mu dilute HCl asidhi uye mu chloroform.Xylazine haigone kunyungudika mumvura uye mune alkali mhinduro.
Biochem/physiol Zviito

Xylazine kana yakashandiswa pamwe chete neketamine inoonekwa seine simba uye yakachengeteka anesthetic mumhuka yekuedza.Iyo inozivikanwa kuti inosimudzira kuburitswa kwechiropa kweglucose, iyo inowedzera kune hyperglycemia.
Nzira yekuita

Xylazine inotengeswa seyo hydrochloride munyu seRompun (100 mg / mL) uye Anased (20 mg / mL) injectable solutions for intravenous administration kumabhiza nembwa, maererano.Zviito zve xylazine zvinogona kuchinjwa nehutungamiri hwe yohimbine, indoalkylamine alkaloid, iyo inovhara iyo α2-adrenoreceptors iyo inokurudzirwa nexylazine.
Safety Profile

Chepfu nekupinza, subcutaneous, uye nzira dzemutsinga.Hunhu systemic mhedzisiro: shanduko mukuita kwemota, kudonha kweropa, miosis, pleural thickening, pulse rate kudzikira, somnolence.Kana ichipisa kuti iore inoburitsa hutsi hunotyisa hweNOx uye SOx